Getting drug utilisation related information of subjects in a cohort
Source:vignettes/drug_utilisation.Rmd
drug_utilisation.RmdIntroduction
The DrugUtilisation package includes a range of functions that add
drug-related information of subjects in OMOP CDM tables and cohort
tables. Essentially, there are two functionalities: add and
summarise. While the first return patient-level information
on drug usage, the second returns aggregate estimates of it. In this
vignette, we will explore these functions and provide some examples for
its usage.
Set up
Mock data
For this vignette we will use mock data contained in the DrugUtilisation package. This mock dataset contains cohorts, we will take “cohort1” as the cohort table of interest from which we want to study drug usage of acetaminophen.
library(DrugUtilisation)
#> Error in get(paste0(generic, ".", class), envir = get_method_env()) :
#> object 'type_sum.accel' not found
cdm <- mockDrugUtilisation(numberIndividual = 200)
cdm$cohort1 |>
dplyr::glimpse()
#> Rows: ??
#> Columns: 4
#> Database: DuckDB v1.1.3 [unknown@Linux 6.8.0-1017-azure:R 4.4.2/:memory:]
#> $ cohort_definition_id <int> 3, 1, 1, 3, 3, 2, 1, 3, 2, 3, 3, 1, 2, 3, 2, 2, 1…
#> $ subject_id <int> 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15…
#> $ cohort_start_date <date> 2004-08-15, 2015-06-19, 2001-07-26, 2008-06-25, …
#> $ cohort_end_date <date> 2005-04-10, 2017-10-21, 2001-12-07, 2012-03-22, …Drug codes
Since we want to characterise acetaminophen and simvastatin usage for subjects in cohort1, we first have to get the codelist with CodelistGenerator:
drugConcepts <- CodelistGenerator::getDrugIngredientCodes(cdm = cdm, name = c("acetaminophen", "simvastatin"))Add drug utilisation information
addNumberExposures()
With the function addNumberExposures()
we can get how many exposures to acetaminophen each patient in our
cohort had during a certain time. There are 2 thing to keep in mind when
using this function:
Time period of interest: The
indexDateandcensorDatearguments refer to the time-period in which we are interested to compute the number of exposure to acetaminophen. The refer to date columns in the cohort table, and by default this are “cohort_start_date” and “cohort_end_date” respectively.Incident or prevalent events? Do we want to consider only those exposures to the drug of interest starting during the time-period (
restrictIncident = TRUE), or do we also want to take into account those that started before but underwent for at least some time during the follow-up period considered (restrictIncident = FALSE)?
In what follows we add a column in the cohort table, with the number of incident exposures during the time patients are in the cohort:
cohort <- addNumberExposures(
cohort = cdm$cohort1, # cohort with the population of interest
conceptSet = drugConcepts, # concepts of the drugs of interest
indexDate = "cohort_start_date",
censorDate = "cohort_end_date",
restrictIncident = TRUE,
nameStyle = "number_exposures_{concept_name}",
name = NULL
)
cohort |>
dplyr::glimpse()
#> Rows: ??
#> Columns: 6
#> Database: DuckDB v1.1.3 [unknown@Linux 6.8.0-1017-azure:R 4.4.2/:memory:]
#> $ cohort_definition_id <int> 3, 2, 1, 2, 3, 1, 3, 2, 1, 2, 3, 1,…
#> $ subject_id <int> 1, 6, 7, 9, 10, 12, 14, 15, 17, 20,…
#> $ cohort_start_date <date> 2004-08-15, 2012-07-24, 2013-06-10…
#> $ cohort_end_date <date> 2005-04-10, 2012-08-10, 2013-08-26…
#> $ number_exposures_161_acetaminophen <int> 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,…
#> $ number_exposures_36567_simvastatin <int> 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,…addNumberEras()
This function works like the previous one, but calculates the
number of eras instead of exposures. The difference
between these two is given by the gapEra argument:
consecutive drug exposures separated by less than the days specified in
gapEra, are collapsed together into the same era.
Next we compute the number of eras, considering a gap of 3 days.
Additionally, we use the argument nameStyle so the new
columns are only identified by the concept name, instead of using the
prefix “number_eras_” set by default.
cohort <- addNumberEras(
cohort = cdm$cohort1, # cohort with the population of interest
conceptSet = drugConcepts, # concepts of the drugs of interest
indexDate = "cohort_start_date",
censorDate = "cohort_end_date",
gapEra = 3,
restrictIncident = TRUE,
nameStyle = "{concept_name}",
name = NULL
)
cohort |>
dplyr::glimpse()
#> Rows: ??
#> Columns: 6
#> Database: DuckDB v1.1.3 [unknown@Linux 6.8.0-1017-azure:R 4.4.2/:memory:]
#> $ cohort_definition_id <int> 3, 2, 1, 2, 3, 1, 3, 2, 1, 2, 3, 1, 3, 3, 3, 1, 1…
#> $ subject_id <int> 1, 6, 7, 9, 10, 12, 14, 15, 17, 20, 21, 22, 23, 2…
#> $ cohort_start_date <date> 2004-08-15, 2012-07-24, 2013-06-10, 2017-11-04, …
#> $ cohort_end_date <date> 2005-04-10, 2012-08-10, 2013-08-26, 2018-02-24, …
#> $ `36567_simvastatin` <int> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
#> $ `161_acetaminophen` <int> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…daysExposed
This argument set to TRUE will add a column specifying the time in
days a person has been exposed to the drug of interest. Take note that
gapEra and restrictIncident will be taken into
account for this calculation:
Drug eras: exposed time will be based on drug eras according to
gapEra.Incident exposures: if
restrictIncident = TRUE, exposed time will consider only those drug exposures starting after indexDate, while ifrestrictIncident = FALSE, exposures that started before indexDate and ended afterwards will also be taken into account.
The subfunction to get only this information is
addDaysExposed().
timeToExposure
If set to TRUE, a column will be added that shows the number of days
until the first exposure occurring within the considered time window.
Notice that the value of restrictIncident will be taken
into account: if TRUE, the time to the first incident exposure during
the time interval is measured; otherwise, exposures that start before
the indexDate and end afterwards will be considered (in
these cases, time to exposure is 0).
The subfunction to get only this information is
addTimeToExposure()
initialQuantity and cumulativeQuantity
These, if TRUE, will add a column each specifying which was the
initial quantity prescribed at the start of the first exposure
considered (initialQuantity), and the cumulative quantity
taken throughout the exposures in the considered time-window
(cumulativeQuantity).
Quantities are measured at conceptSet level not ingredient. Notice
that for both measures restrictIncident is considered,
while gapEra is used for the
cumulative quantity.
The subfunctions to get this information are
addInitialQuantity() and
addCumulativeQuantity() respectively.
initialDailyDose and cumulativeDose
If initialDailyDose is TRUE, a column will be add
specifying for each of the ingredients in a conceptSet which was the
initial daily dose given. The cumulativeDose will measure
for each ingredient the total dose taken throughout the exposures
considered in the time-window. Recall that restrictIncident
is considered in these calculations, and that the cumulative dose also
considers gapEra.
The subfunctions to get this information are
addInitialDailyDose() and addCumulativeDose()
respectively.
addDrugUtilisation()
All the explained add functions are
subfunctions of the more comprehensive
addDrugUtilisation(). This broader
function computes multiple drug utilization metrics.
addDrugUtilisation(
cohort,
indexDate = "cohort_start_date",
censorDate = "cohort_end_date",
ingredientConceptId = NULL,
conceptSet = NULL,
restrictIncident = TRUE,
gapEra = 1,
numberExposures = TRUE,
numberEras = TRUE,
daysExposed = TRUE,
timeToExposure = TRUE,
initialQuantity = TRUE,
cumulativeQuantity = TRUE,
initialDailyDose = TRUE,
cumulativeDose = TRUE,
nameStyle = "{value}_{concept_name}_{ingredient}",
name = NULL
)Using
addDrugUtilisation()is recommended when multiple parameters are needed, as it is more computationally efficient than chaining the different subfunctions.If
conceptSetis NULL, it will be produced from descendants of given ingredients.nameStyleargument allows customisation of the names of the new columns added by the function, following the glue package style.By default it returns a temporal table, but if
nameis not NULL a permanent table with the defined name will be computed in the database.
Use case
In what follows we create a permanent table “drug_utilisation_example” in the database with the information on dosage and quantity of the ingredients 1125315 (acetaminophen) and 1503297 (metformin). We are interested in exposures happening from cohort end date, until the end of the patient’s observation data. Additionally, we define an exposure era using a gap of 7 days, and we only consider incident exposures during that time.
cdm$drug_utilisation_example <- cdm$cohort1 |>
# add end of current observation date with the package PatientProfiels
PatientProfiles::addFutureObservation(futureObservationType = "date") |>
# add the targeted drug utilisation measures
addDrugUtilisation(
indexDate = "cohort_end_date",
censorDate = "future_observation",
ingredientConceptId = c(1125315, 1503297),
conceptSet = NULL,
restrictIncident = TRUE,
gapEra = 7,
numberExposures = FALSE,
numberEras = FALSE,
daysExposed = FALSE,
timeToExposure = FALSE,
initialQuantity = TRUE,
cumulativeQuantity = TRUE,
initialDailyDose = TRUE,
cumulativeDose = TRUE,
nameStyle = "{value}_{concept_name}_{ingredient}",
name = "drug_utilisation_example"
)
cdm$drug_utilisation_example |>
dplyr::glimpse()
#> Rows: ??
#> Columns: 17
#> Database: DuckDB v1.1.3 [unknown@Linux 6.8.0-1017-azure:R 4.4.2/:memory:]
#> $ cohort_definition_id <int> 3,…
#> $ subject_id <int> 1,…
#> $ cohort_start_date <date> 2…
#> $ cohort_end_date <date> 2…
#> $ future_observation <date> 2…
#> $ cumulative_quantity_ingredient_1503297_descendants <dbl> 0,…
#> $ cumulative_quantity_ingredient_1125315_descendants <dbl> 0,…
#> $ initial_quantity_ingredient_1503297_descendants <dbl> 0,…
#> $ initial_quantity_ingredient_1125315_descendants <dbl> 0,…
#> $ initial_exposure_duration_ingredient_1503297_descendants <int> NA…
#> $ initial_exposure_duration_ingredient_1125315_descendants <int> NA…
#> $ days_prescribed_ingredient_1125315_descendants <int> 0,…
#> $ days_prescribed_ingredient_1503297_descendants <int> 0,…
#> $ cumulative_dose_milligram_ingredient_1125315_descendants_1125315 <dbl> 0,…
#> $ initial_daily_dose_milligram_ingredient_1125315_descendants_1125315 <dbl> 0,…
#> $ cumulative_dose_milligram_ingredient_1503297_descendants_1503297 <dbl> 0,…
#> $ initial_daily_dose_milligram_ingredient_1503297_descendants_1503297 <dbl> 0,…Summarise drug utilisation information
The information given by addDrugUtilisation() or its
sub-functions is at patient level. If we are interested in aggregated
estimates for these measure we can use
summariseDrugUtilisation().
summariseDrugUtilisation()
This function will provide the desired estimates (set in the argument
estimates) of the targeted drug utilisation measures.
Similar to addDrugUtilisation(), by setting TRUE or FALSE
each of the drug utilisation measures, the user can choose which
measures to obtain.
duResults <- summariseDrugUtilisation(
cohort = cdm$cohort1,
strata = list(),
estimates = c(
"q25", "median", "q75", "mean", "sd", "count_missing",
"percentage_missing"
),
indexDate = "cohort_start_date",
censorDate = "cohort_end_date",
ingredientConceptId = c(1125315, 1503297),
conceptSet = NULL,
restrictIncident = TRUE,
gapEra = 7,
numberExposures = TRUE,
numberEras = TRUE,
daysExposed = TRUE,
timeToExposure = TRUE,
initialExposureDuration = TRUE,
initialQuantity = TRUE,
cumulativeQuantity = TRUE,
initialDailyDose = TRUE,
cumulativeDose = TRUE
)
duResults |>
dplyr::glimpse()
#> Rows: 426
#> Columns: 13
#> $ result_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
#> $ cdm_name <chr> "DUS MOCK", "DUS MOCK", "DUS MOCK", "DUS MOCK", "DUS …
#> $ group_name <chr> "cohort_name", "cohort_name", "cohort_name", "cohort_…
#> $ group_level <chr> "cohort_1", "cohort_1", "cohort_1", "cohort_1", "coho…
#> $ strata_name <chr> "overall", "overall", "overall", "overall", "overall"…
#> $ strata_level <chr> "overall", "overall", "overall", "overall", "overall"…
#> $ variable_name <chr> "number records", "number subjects", "number exposure…
#> $ variable_level <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
#> $ estimate_name <chr> "count", "count", "q25", "median", "q75", "mean", "sd…
#> $ estimate_type <chr> "integer", "integer", "integer", "integer", "integer"…
#> $ estimate_value <chr> "66", "66", "0", "0", "0", "0.151515151515152", "0.50…
#> $ additional_name <chr> "overall", "overall", "concept_set", "concept_set", "…
#> $ additional_level <chr> "overall", "overall", "ingredient_1125315_descendants…As seen below, the result of this function is a
summarised_result object. For more information on these
class of objects see omopgenerics package.
Additionally, the strata argument will provide the
estimates for different stratifications defined by columns in the
cohort. For instance, we can add a column indicating the sex, and
another indicating if the subject is older than 50, and use those to
stratify by sex and age, together and separately as follows:
duResults <- cdm$cohort1 |>
# add age and sex
PatientProfiles::addDemographics(
age = TRUE,
ageGroup = list("<=50" = c(0, 50), ">50" = c(51, 150)),
sex = TRUE,
priorObservation = FALSE,
futureObservation = FALSE
) |>
# drug utilisation
summariseDrugUtilisation(
strata = list("age_group", "sex", c("age_group", "sex")),
estimates = c("mean", "sd", "count_missing", "percentage_missing"),
indexDate = "cohort_start_date",
censorDate = "cohort_end_date",
ingredientConceptId = c(1125315, 1503297),
conceptSet = NULL,
restrictIncident = TRUE,
gapEra = 7,
numberExposures = TRUE,
numberEras = TRUE,
daysExposed = TRUE,
timeToExposure = TRUE,
initialQuantity = TRUE,
cumulativeQuantity = TRUE,
initialDailyDose = TRUE,
cumulativeDose = TRUE
)
duResults |>
dplyr::glimpse()
#> Rows: 1,968
#> Columns: 13
#> $ result_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
#> $ cdm_name <chr> "DUS MOCK", "DUS MOCK", "DUS MOCK", "DUS MOCK", "DUS …
#> $ group_name <chr> "cohort_name", "cohort_name", "cohort_name", "cohort_…
#> $ group_level <chr> "cohort_1", "cohort_1", "cohort_1", "cohort_1", "coho…
#> $ strata_name <chr> "age_group", "age_group", "age_group", "age_group", "…
#> $ strata_level <chr> "<=50", "<=50", "<=50", "<=50", "<=50", "<=50", "<=50…
#> $ variable_name <chr> "number records", "number subjects", "number exposure…
#> $ variable_level <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
#> $ estimate_name <chr> "count", "count", "mean", "sd", "count_missing", "per…
#> $ estimate_type <chr> "integer", "integer", "numeric", "numeric", "integer"…
#> $ estimate_value <chr> "63", "63", "0.158730158730159", "0.447442524921401",…
#> $ additional_name <chr> "overall", "overall", "concept_set", "concept_set", "…
#> $ additional_level <chr> "overall", "overall", "ingredient_1503297_descendants…The estimates obtained in this last part correspond to the mean
(mean) and standard deviation (sd) of those
that had information on dose and quantity, and the number
(count_missing) (and percentage
(percentage_missing)) of subjects with missing
information.
tableDrugUtilisation()
Results from summariseDrugUtilisation() can be nicely
visualised in a tabular format using the function
tableDrugUtilisation().
tableDrugUtilisation(duResults)
#> ℹ <median> (<q25> - <q75>) has not been formatted.| censor_date | cohort_table_name | gap_era | index_date | restrict_incident | concept_set | ingredient | variable_name | estimate_name |
cdm_name
|
|---|---|---|---|---|---|---|---|---|---|
| DUS MOCK | |||||||||
| cohort_1; <=50; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 63 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 63 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.16 (0.45) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.16 (0.51) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 55 (87.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 800.62 (1,209.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 56 (88.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 108.71 (105.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 5.79 (17.21) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 3.59 (13.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 2.56 (11.06) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 5.16 (15.96) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 56 (88.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 169.00 (120.53) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 55 (87.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 499.25 (563.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.14 (0.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.13 (0.34) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 53.41 (333.70) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 54.08 (210.81) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 55.51 (335.44) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 56.22 (215.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 3,599.55 (18,139.68) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 207.39 (1,574.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 3,430.17 (10,342.89) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 282.65 (1,900.60) |
| cohort_1; >50; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 3 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 3 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 1.00 (1.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 1 (33.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 411.50 (309.01) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 3 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 23.67 (40.13) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 10.33 (17.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 3 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 1 (33.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 138.50 (58.69) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 1.00 (1.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 86.00 (128.73) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 86.00 (128.73) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 5,756.07 (9,863.94) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 29.32 (46.44) |
| cohort_1; <=50; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 28 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 28 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.11 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.25 (0.65) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 26 (92.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 285.50 (38.89) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 23 (82.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 104.00 (126.39) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 2.32 (9.76) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 6.82 (19.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 4.86 (16.12) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 1.25 (4.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 23 (82.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 118.00 (100.79) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 26 (92.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 100.50 (112.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.21 (0.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.07 (0.26) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 17.71 (61.18) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 12.07 (59.71) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 22.43 (82.12) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 15.64 (78.57) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 5,063.67 (22,769.17) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 465.44 (2,359.55) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 1,853.87 (7,431.16) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 26.32 (128.89) |
| cohort_1; <=50; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 35 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 35 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.20 (0.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.09 (0.37) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 29 (82.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 972.33 (1,380.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 33 (94.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 120.50 (48.79) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 8.57 (21.13) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 1.00 (4.17) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 0.71 (3.01) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 8.29 (20.61) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 33 (94.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 296.50 (31.82) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 29 (82.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 632.17 (597.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.09 (0.37) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.17 (0.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 81.97 (445.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 87.69 (274.93) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 81.97 (445.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 88.69 (278.58) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 2,428.25 (13,607.07) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 0.95 (3.95) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 4,691.21 (12,146.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 487.71 (2,544.90) |
| cohort_1; >50; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 1 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 1 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 1 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 1 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | - |
| cohort_1; >50; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 2 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 2 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.50 (0.71) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 1 (50.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 2 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 0.50 (0.71) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 0.50 (0.71) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 2 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 1 (50.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.50 (0.71) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 12.00 (16.97) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 12.00 (16.97) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 61.22 (86.58) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 2.55 (3.61) |
| cohort_1; overall; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 66 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 66 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.20 (0.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.15 (0.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 56 (84.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 722.80 (1,084.12) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 59 (89.4 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 108.71 (105.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 6.61 (18.60) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 3.42 (13.07) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 2.44 (10.82) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 5.39 (15.91) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 59 (89.4 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 169.00 (120.53) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 56 (84.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 427.10 (519.91) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.14 (0.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.17 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 50.98 (326.10) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 55.53 (207.23) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 52.98 (327.81) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 57.58 (212.10) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 3,435.93 (17,732.23) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 197.96 (1,538.24) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 3,535.89 (10,260.13) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 271.13 (1,857.00) |
| cohort_1; overall; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 29 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 29 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.17 (0.54) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.24 (0.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 26 (89.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 400.33 (200.79) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 24 (82.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 104.00 (126.39) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 4.66 (15.81) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 6.59 (18.89) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 4.69 (15.85) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 2.24 (7.02) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 24 (82.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 118.00 (100.79) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 26 (89.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 127.00 (91.80) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.21 (0.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.14 (0.44) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 17.10 (60.17) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 19.72 (71.67) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 21.66 (80.75) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 23.17 (87.16) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 4,889.06 (22,378.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 449.39 (2,318.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,381.18 (7,830.29) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 28.27 (127.00) |
| cohort_1; overall; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 37 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 37 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.22 (0.48) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.08 (0.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 30 (81.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 861.00 (1,294.31) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 35 (94.6 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 120.50 (48.79) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 8.14 (20.62) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 0.95 (4.05) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 0.68 (2.93) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 7.86 (20.11) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 35 (94.6 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 296.50 (31.82) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 30 (81.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 555.71 (581.66) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.08 (0.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.19 (0.40) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 77.54 (433.06) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 83.59 (267.77) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 77.54 (433.06) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 84.54 (271.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 2,297.00 (13,235.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 0.90 (3.85) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 4,440.94 (11,851.88) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 461.48 (2,475.70) |
| cohort_2; <=50; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 51 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 51 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.14 (0.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.24 (0.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 46 (90.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 178.60 (255.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 40 (78.4 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 436.91 (723.62) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 4.41 (13.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 9.22 (19.40) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 8.43 (17.85) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 3.53 (11.97) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 40 (78.4 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 724.55 (1,102.02) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 46 (90.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 182.00 (168.31) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.22 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.10 (0.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 86.76 (379.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 21.47 (99.72) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 87.08 (379.81) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 33.39 (181.83) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 25,634.49 (85,811.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 2,624.79 (15,813.75) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,083.35 (6,610.92) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 42.88 (236.52) |
| cohort_2; <=50; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 27 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 27 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.11 (0.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.22 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 24 (88.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 205.00 (329.31) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 21 (77.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 150.33 (220.69) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 4.81 (14.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 8.89 (19.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 8.89 (19.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 4.81 (14.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 21 (77.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 779.33 (1,277.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 24 (88.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 128.67 (103.18) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.22 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.11 (0.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 49.41 (240.14) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 12.85 (46.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 49.41 (240.14) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 12.85 (46.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 21,126.45 (71,475.11) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 4,868.94 (21,672.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,005.59 (5,919.70) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 69.68 (320.44) |
| cohort_2; <=50; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 24 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 24 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.17 (0.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.25 (0.53) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 22 (91.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 139.00 (196.58) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 19 (79.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 780.80 (988.51) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 3.96 (13.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 9.58 (19.83) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 7.92 (16.35) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 2.08 (9.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 19 (79.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 658.80 (992.52) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 22 (91.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 262.00 (265.87) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.21 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.08 (0.28) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 128.79 (494.95) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 31.17 (137.75) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 129.46 (494.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 56.50 (261.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 30,706.03 (100,906.10) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 100.11 (349.98) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,170.83 (7,441.80) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 12.73 (61.20) |
| cohort_2; overall; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 51 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 51 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.14 (0.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.24 (0.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 46 (90.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 178.60 (255.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 40 (78.4 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 436.91 (723.62) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 4.41 (13.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 9.22 (19.40) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 8.43 (17.85) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 3.53 (11.97) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 40 (78.4 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 724.55 (1,102.02) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 46 (90.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 182.00 (168.31) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.22 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.10 (0.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 86.76 (379.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 21.47 (99.72) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 87.08 (379.81) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 33.39 (181.83) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 25,634.49 (85,811.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 2,624.79 (15,813.75) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,083.35 (6,610.92) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 42.88 (236.52) |
| cohort_2; overall; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 27 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 27 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.11 (0.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.22 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 24 (88.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 205.00 (329.31) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 21 (77.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 150.33 (220.69) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 4.81 (14.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 8.89 (19.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 8.89 (19.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 4.81 (14.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 21 (77.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 779.33 (1,277.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 24 (88.9 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 128.67 (103.18) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.22 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.11 (0.32) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 49.41 (240.14) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 12.85 (46.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 49.41 (240.14) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 12.85 (46.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 21,126.45 (71,475.11) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 4,868.94 (21,672.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,005.59 (5,919.70) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 69.68 (320.44) |
| cohort_2; overall; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 24 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 24 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.17 (0.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.25 (0.53) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 22 (91.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 139.00 (196.58) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 19 (79.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 780.80 (988.51) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 3.96 (13.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 9.58 (19.83) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 7.92 (16.35) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 2.08 (9.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 19 (79.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 658.80 (992.52) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 22 (91.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 262.00 (265.87) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.21 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.08 (0.28) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 128.79 (494.95) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 31.17 (137.75) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 129.46 (494.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 56.50 (261.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 30,706.03 (100,906.10) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 100.11 (349.98) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 2,170.83 (7,441.80) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 12.73 (61.20) |
| cohort_3; <=50; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 71 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 71 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.24 (0.55) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.24 (0.52) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 58 (81.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 1,281.31 (2,611.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 57 (80.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 812.64 (990.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 9.38 (21.92) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 6.83 (22.48) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 4.86 (14.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 8.59 (20.89) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 57 (80.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 548.86 (623.05) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 58 (81.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 603.00 (1,050.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.20 (0.40) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.20 (0.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 89.37 (295.29) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 89.31 (329.54) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 94.63 (307.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 100.49 (379.93) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 12,536.55 (46,614.74) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 289.25 (1,215.14) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 5,384.64 (14,803.58) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 380.78 (1,901.85) |
| cohort_3; >50; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 12 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 12 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.08 (0.29) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.33 (0.65) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 11 (91.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 9 (75.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 78.67 (124.33) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 0.42 (1.44) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 15.92 (51.75) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 8.42 (25.85) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 0.42 (1.44) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 9 (75.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 296.33 (480.46) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 11 (91.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.33 (0.65) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.08 (0.29) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 76.75 (263.98) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 66.25 (229.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 76.75 (263.98) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 66.25 (229.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 5,180.08 (17,438.09) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 38.85 (114.76) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 162.86 (564.15) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 0.20 (0.71) |
| cohort_3; <=50; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 33 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 33 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.24 (0.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.15 (0.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 26 (78.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 1,976.43 (3,464.24) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 28 (84.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 1,047.60 (1,292.92) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 8.97 (18.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 3.18 (9.59) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 3.18 (9.59) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 8.94 (18.40) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 28 (84.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 308.40 (339.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 26 (78.8 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 534.29 (600.76) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.15 (0.36) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.21 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 45.85 (161.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 106.03 (327.99) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 45.85 (161.64) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 117.42 (363.26) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 14,435.20 (54,907.07) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 231.40 (764.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 4,669.78 (11,540.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 91.37 (284.10) |
| cohort_3; <=50; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 38 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 38 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.24 (0.59) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.32 (0.62) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 32 (84.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 470.33 (707.54) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 29 (76.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 682.11 (839.34) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 9.74 (24.77) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 10.00 (29.22) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 6.32 (16.99) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 8.29 (23.08) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 29 (76.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 682.44 (719.01) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 32 (84.2 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 683.17 (1,483.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.24 (0.43) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.18 (0.46) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 127.16 (373.12) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 74.79 (334.57) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 137.00 (389.61) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 85.79 (398.10) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 10,887.73 (38,698.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 339.49 (1,510.79) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 6,005.45 (17,279.29) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 632.10 (2,575.59) |
| cohort_3; >50; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 6 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 6 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.50 (0.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 6 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 4 (66.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 118.00 (147.08) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 30.17 (73.40) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 15.17 (36.66) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 4 (66.7 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 440.00 (581.24) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 6 (100.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.50 (0.84) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 152.83 (373.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 152.83 (373.38) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 10,093.49 (24,710.83) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 11.03 (21.16) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 0.00 (0.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 0.00 (0.00) |
| cohort_3; >50; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 6 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 6 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.17 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.17 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 5 (83.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 5 (83.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 0.83 (2.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 1.67 (4.08) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 1.67 (4.08) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 0.83 (2.04) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 5 (83.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 5 (83.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | - |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.17 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.17 (0.41) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 0.67 (1.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 132.50 (324.56) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 0.67 (1.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 132.50 (324.56) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 266.67 (653.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 66.67 (163.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 325.71 (797.83) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 0.41 (1.00) |
| cohort_3; overall; overall | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 83 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 83 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.22 (0.52) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.25 (0.54) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 69 (83.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 1,235.36 (2,514.90) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 66 (79.5 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 683.12 (939.21) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 8.08 (20.50) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 8.14 (28.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 5.37 (16.11) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 7.41 (19.53) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 66 (79.5 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 504.29 (595.07) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 69 (83.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 632.50 (1,015.23) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.22 (0.44) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.18 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 87.54 (289.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 85.98 (315.96) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 92.05 (299.78) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 95.54 (361.16) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 11,472.97 (43,617.78) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 253.05 (1,126.99) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 4,629.69 (13,803.33) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 325.75 (1,762.34) |
| cohort_3; overall; Female | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 39 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 39 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.21 (0.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.21 (0.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 32 (82.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 1,976.43 (3,464.24) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 32 (82.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 782.00 (1,150.56) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 7.59 (17.27) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 7.33 (29.73) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 5.03 (16.54) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 7.56 (17.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 32 (82.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 346.00 (370.48) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 32 (82.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 534.29 (600.76) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.21 (0.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.18 (0.39) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 62.31 (204.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 89.72 (303.47) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 62.31 (204.63) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 99.36 (336.10) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 13,767.25 (51,201.87) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 197.50 (706.19) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 3,951.35 (10,726.51) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 77.32 (262.84) |
| cohort_3; overall; Male | |||||||||
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number records | N | 44 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | overall | overall | number subjects | N | 44 |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number exposures | Mean (SD) | 0.23 (0.57) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number exposures | Mean (SD) | 0.30 (0.59) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | missing N (%) | 37 (84.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | time to exposure | Mean (SD) | 494.29 (649.00) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | missing N (%) | 34 (77.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | time to exposure | Mean (SD) | 613.90 (820.20) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | cumulative quantity | Mean (SD) | 8.52 (23.19) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | cumulative quantity | Mean (SD) | 8.86 (27.30) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial quantity | Mean (SD) | 5.68 (15.91) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial quantity | Mean (SD) | 7.27 (21.58) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | missing N (%) | 34 (77.3 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | initial exposure duration | Mean (SD) | 615.10 (710.56) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | missing N (%) | 37 (84.1 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | initial exposure duration | Mean (SD) | 730.71 (1,360.05) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | number eras | Mean (SD) | 0.23 (0.42) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | number eras | Mean (SD) | 0.18 (0.45) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days exposed | Mean (SD) | 109.91 (348.88) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days exposed | Mean (SD) | 82.66 (330.11) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | overall | days prescribed | Mean (SD) | 118.41 (364.49) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | overall | days prescribed | Mean (SD) | 92.16 (385.86) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | cumulative dose milligram | Mean (SD) | 9,439.40 (36,086.67) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1125315_descendants | acetaminophen | initial daily dose milligram | Mean (SD) | 302.29 (1,405.73) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | cumulative dose milligram | Mean (SD) | 5,230.94 (16,151.59) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | missing N (%) | 0 (0.0 %) |
| cohort_end_date | temp | 7 | cohort_start_date | TRUE | ingredient_1503297_descendants | metformin | initial daily dose milligram | Mean (SD) | 545.96 (2,399.19) |